Relaxin , a member of the insulin superfamily has been shown to expressed in porcine adipose tissue  Domest Anim Endocrinol. 2005 Jul;29(1):186-92   and may have a role in appetite regulation.

The insulin-Like-Peptide, Relaxin-3 (INSL-7)  J Biol Chem. 2003 Dec 12;278(50):50765-70   is expressed in the brainstem (nucleus incertus) from where neurons project to the hypothalamus.  Endocrinology. 2005 Aug;146(8):3295-300     Relaxin-3 as well as GPCR135  J Biol Chem. 2003 Dec 12;278(50):50754-64    and LGR7 receptors   J Pharmacol Exp Ther. 2005 May;313(2):677-87    which bind Relaxin-3 are expressed in the PVN (paraventricular nucleus) of the hypothalamus which is a well recognised site involved with appetite regulation. Injection of human relaxin-3 (H3) to satiated rats centrally (intracerebroventricular or into the PVN) significantly increased food intake within an hour of administration.  Endocrinology. 2005 Aug;146(8):3295-300    without inducing changes in hypothalamic neuropeptide Y, proopiomelanocortin, or AgRP mRNA expression.  The physiological role if any played by Relaxin in appetite control remains to be clarified.

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    This page was last updated on: 27/01/2007

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